Beta-blockade in experimental fluid-resuscitated sepsis: acute haemodynamic effects of esmolol differ in predicted survivors and non-survivors
نویسندگان
چکیده
Introduction Beta-blockade therapy during sepsis has a sound rationale in view of its cardiac, metabolic, inflammatory and other effects [1]. Whether it is safe and efficacious in both good prognosis and poor prognosis patients is yet to be ascertained. We have developed a 72-h fluid-resuscitated rat model of faecal peritonitis, where prognosis can be accurately predicted as early as 6 h post-insult based on the degree of myocardial depression (low stroke volume, high heart rate)[2]. This model offers a useful means of testing safety and efficacy.
منابع مشابه
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015